GSH with each dose of chemotherapy
(Taxol/CBDCA) vs. Placebo with each dose of chemotherapy (TAXOL/CBDCA)
Treatment Cycle = 21 days
Observation Cycle Length = every 3 months for one year post chemotherapy
Mandatory research blood draw
Scheduled to undergo treatment with TAXOL at 150-200 mg/m2 and CBDCA at AUC = 5-7 every 21 or 28 days for 6 cycles for at least 3 months (90 days). Alternativley, pacitaxel can be prescribed at 80 mg/m2 weekly for at least 3 months (90 days) without break, with same CBDCA dose of AUC = 5-7 every 21 days. Additional chemotherapy agents are allowed (bevacizumab, etoposide, etc.) per physician descretion, as long as they are known to be neurotoxic. Note: Patients will idealy begin GSH therapy prior to their first dose if this chemotherapy, but must begin GSH therapy prior to their second dose of chemotherapy.
- Pre-existing hx. of peripheral neuropathy > grade 1 for any cause
- Prior TAXOL and/or CBDCA chemotherapy