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Home > Wellness > Health Library > Chronic Fatigue: Antidepressants
Antidepressants do not cure CFS. They may relieve symptoms
such as fatigue, sleep problems, difficulty concentrating, and pain. But they
will not affect the course of the illness or the speed of recovery.
Antidepressants that are commonly used to treat
chronic fatigue syndrome (CFS) include:
When these medicines are used to treat CFS, they may be given
in lower doses than the amounts used to treat depression.
choice of medicine may depend on the symptoms that are most bothersome, because
each medicine has somewhat different side effects. For example:
If depression has been diagnosed along with CFS,
antidepressants may be used to treat depression as well.
FDA advisories. The U.S. Food and Drug Administration (FDA)
Do not suddenly stop taking antidepressants. These medicines
must be gradually tapered off under your doctor's supervision.
U.S. Food and Drug Administration (2005).
FDA Public Health Advisory: Paroxetine. Available
April 22, 2011
Anne C. Poinier, MD - Internal Medicine & Nancy Greenwald, MD - Physical Medicine and Rehabilitation
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