Multiple Sclerosis

National Organization for Rare Disorders, Inc.

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Important
It is possible that the main title of the report Multiple Sclerosis is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal cord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occurs randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.

Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).

Supporting Organizations

American Autoimmune & Related Diseases

22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Website: http://www.aarda.org/

AutoImmunity Community

Website: https://www.facebook.com/autoimmunityforum

Child Neurology Foundation

201 Chicago Ave, #200
Minneapolis, MN 55415
USA
Tel: (952)641-6100
Fax: (952)881-6276
Tel: (877)263-5430
Email: jstone@childneurologyfoundation.org
Website: http://www.childneurologyfoundation.org

Christopher & Dana Reeve Foundation

636 Morris Turnpike, Suite 3A
Short Hills, NJ 7078
USA
Tel: (973)379-2690
Fax: (973)912-9433
Tel: (800)225-0292
Email: prc@ChristopherReeve.org
Website: http://www.christopherreeve.org

Consortium of Multiple Sclerosis Centers

359 Main Street
Suite A
Hackensack, NJ 7601
Tel: (201)487-1050
Fax: (201)678-2290
Email: info@mscare.org
Website: http://www.mscare.org

European Society for Immunodeficiencies

1-3 rue de Chantepoulet
Geneva, CH 1211
Switzerland
Tel: 410229080484
Fax: 41229069140
Email: esid@kenes.com
Website: http://www.esid.org

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Website: http://rarediseases.info.nih.gov/GARD/

Multiple Sclerosis Association of America

706 Haddonfield Road
Cherry Hill, NJ 8002
USA
Tel: (856)488-4500
Fax: (856)661-9797
Tel: (800)532-7667
Email: ctalbot@msassociation.org
Website: http://www.msassociation.org/

Multiple Sclerosis Foundation

6520 North Andrews Avenue
Ft. Lauderdale, FL 33309-2130
Tel: (954)776-6805
Fax: (954)938-8708
Tel: (800)225-6495
Email: admin@msfocus.org
Website: http://www.msfocus.org

Multiple Sclerosis International Federation

3rd Floor Skyline House
200 Union Street
London, SE1 0LX
United Kingdom
Tel: 4402076201911
Fax: 4402076201922
Email: info@msif.org
Website: http://www.msif.org/en/

NIH/National Institute of Neurological Disorders and Stroke

P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
Website: http://www.ninds.nih.gov/

National Multiple Sclerosis Society

733 Third Avenue, Third Floor
New York, NY 10017-3288
USA
Tel: (800) 344-4867
Email: contactusnmss@nmss.org
Website: http://www.nationalmssociety.org

New Horizons Un-Limited, Inc.

811 East Wisconsin Ave
P.O. Box 510034
Milwaukee, WI 53203
USA
Tel: (414)299-0124
Fax: (414)347-1977
Email: horizons@new-horizons.org
Website: http://www.new-horizons.org

PLAN Institute for Caring Citizenship

Suite 260 - 3665 Kingsway
Vancouver
British Columbia, V5R 5W2
Canada
Tel: 6044399566
Fax: 6044397001
Email: inquiries@planinstitute.ca
Website: http://www.planinstitute.ca/?q=learnfromus/library

Spastic Paraplegia Foundation

5305 Miramar Ln
Colleyville, TX 76034
USA
Tel: (877)773-4483
Email: information@sp-foundation.org
Website: http://sp-foundation.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  3/29/2012
Copyright  2007 National Organization for Rare Disorders, Inc.